Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases

Table 3

Cxs/Cx-channels in BBB in CNS pathology.

CNS pathology	Cxs/Cx channel remodeling	BBB dysfunction	Reference
MOG-induced EAE mouse model	Deletion of both Cx30 and Cx43	None	[126]
Carrageenan-induced inflammatory pain rat model	Not mentioned	Increased expression of ZO-1 in TJs and permeability of the BBB	[92]
MCAO mouse model	Cx43 ^+/−, GJIC reduction	Weakened barrier function of BBB and exacerbated ischemic injury	[98]
Age-related neurodegenerative disease mouse model	Increased expression and relocalization of Cx43 in ECs	An increase in the permeability of the BBB without change of ZO-1	[108]
4-AP-induced epilepsy rat model	Gradually elevated expression of Cx43 and GJIC remodeling	Not mentioned	[118]
HIV-infected neuroAIDS macaque model	HIV amplified by GJs	Compromised BBB integrity	[123]

Cx: connexin; TJs: tight junctions; GJs: gap junctions; ZO: Zona occludin; GJIC: gap junction intercellular communication; BBB: brain-blood barrier; 4-AP: 4-aminopyridine.