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Neural Plasticity
Volume 2018, Article ID 6589608, 5 pages
Research Article

Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats

1Department of Psychology, Jiangsu University Medical School, Zhenjiang 212013, China
2School of Life Science, Nanjing University of Chinese Medicine, Nanjing 210023, China
3Department of Neurosurgery, Baylor Scott & White Health, Temple, TX 76358, USA
4Department of Surgery, College of Medicine, Texas A&M University, Temple, TX 76354, USA
5Department of Pharmaceutical Sciences, College of Pharmacy, Texas A&M University, College Station, TX 77843, USA
6School of Psychology, Nanjing Forest Police College, Nanjing 210023, China

Correspondence should be addressed to Simeng Gu; moc.621@7002_msg

Received 29 December 2017; Revised 2 February 2018; Accepted 26 March 2018; Published 3 May 2018

Academic Editor: Fang Pan

Copyright © 2018 Simeng Gu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Previously, we have shown that Danshen-Honghua (DSHH) for cognitive deficits after ischemia induced impairments of the hippocampus. Here, we investigate the effects of DSHH on stress-induced depression in menopausal rats. Methods. A rat model with menopausal depression was established with bilateral ovariectomies in female SD rats followed by chronic mild stress treatment for 21 days. 40 rats were randomly divided into the sham surgery group (sham surgery and no stress treatment), surgery group (surgery with no stress treatment), surgery/stress group (surgery and stress treatment), fluoxetine group (2.4 mg·kg−1, with surgery and stress treatment), and DSHH group (35 g·kg−1, with surgery and stress treatment). The rats in the last two groups were treated with stresses together with intragastric drug administration for three weeks after the surgery. Then open-field locomotor scores and sucrose intake were tested for behavior changes. Also, the levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and cortisone were determined by high-performance liquid chromatography (HPLC). Serum estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were determined by radioimmunoassay. Results. The results of open-field locomotor scores, sucrose intake in both the fluoxetine group and DSHH group, were significantly higher than those of the surgery/stress group (). Serum LH, FSH, and cortisone levels in both the DSHH group and fluoxetine group were significantly lower than those in the surgery/stress group (). Serum E2 levels in these groups were slightly increased in these medicine groups (). The monoamine levels in the DSHH group were much higher than those in the surgery/stress group (). Conclusion. DSHH can ameliorate stress-induced depressed syndromes in the surgery/stressed rats via regulating LH and FSH levels as well as monoamine levels.