Review Article
Progress in Gene Therapy to Prevent Retinal Ganglion Cell Loss in Glaucoma and Leber’s Hereditary Optic Neuropathy
Table 1
Promoters typically chosen for transduction of retinal ganglion cells (RGCs) within the eye.
| Promoter | Specificity for RGCs | Strength of expression in RGCs | Off-target labelling | Size (bp) % of AAV cargo | References |
| CMV | + | +++ | Muller glia Amacrine cells Bipolar cells | (508–800) (10–17%) | [10–14] |
| CAG | + | ++++ | Muller glia Amacrine cells Bipolar cells | (584–1132) (12–24%) | [15–17] |
| SYN1 | +++ | ++ | Amacrine cells | (400–469) (8–10%) | [20, 21] |
| Nefh | ++++ | +++ | | (2251) (48%) | [22] |
| Thy1 | ++++ | ++ | | (6500) (exceeds limit) | [23] |
| Mcp-1 | ++ | +++ | injured cells | 560 (mouse only) (12%) | [24] |
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