Exposure to Patterned Auditory Stimuli during Acute Stress Prevents Despair-Like Behavior in Adult Mice That Were Previously Housed in an Enriched Environment in Combination with Auditory Stimuli

Figure 7

Effects of preexposure to standard conditions, environmental enrichment, patterned auditory stimuli, or environmental enrichment plus patterned auditory stimuli during housing and behavior on neuronal activation in the auditory cortex. (a) Representative images of coronal sections within the AuCx showing Arc-labeling. High-power image exhibits the presence of Arc-labeled cells in the AuCx. Scale bars in (a) are equal to 150, 75, 30, or 10 μm. (b) Distribution of Arc-labeled cells in the AuCx. (c) Number of neurons Arc+++. Data represent the mean ± standard error of the mean (SEM, in (b–e)). Significant main effect is showed ().

(a) Arc-labeling

(b) Distribution of categories of Arc-positive cells

(c) Absolute number of intense Arc-positive cells