Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder

Figure 5

Impaired memory in Cdkl5 +/− female mice. (a, b) Passive avoidance task to measure memory that involves contributions from both the hippocampus and amygdala. On the first day (a), no difference was observed between genotypes regarding the latency to enter the dark compartment. On the second day, Cdkl5 +/− () and Cdkl5 −/− () mice showed a decreased latency to enter the dark compartment compared to Cdkl5 +/+ () mice, indicating defects in memory. Values represent . and (Dunn’s test after Kruskall-Wallis).

(a)

(b)