Wnt1 Promotes EAAT2 Expression and Mediates the Protective Effects of Astrocytes on Dopaminergic Cells in Parkinson’s Disease

Figure 6

Wnt1 overexpression decreased the glutamate level in culture medium. SH-SY5Y cells were indirectly cocultured with U251 cells, U251-Wnt1 cells, or U251-EV cells and then treated with or without 50 μM 6-OHDA or 100 ng/ml DKK-1 for 24 h, and the glutamate levels in culture media were detected by ELISA. The data are expressed as percentages relative to the control group. All of the data are presented as the from 7 independent experiments. Differences among groups were examined by using ANOVA followed by Tukey-Kramer tests for post hoc multiple comparisons. value = 15.87, , , and .