The Modulatory Effect of Cerebrovascular Burden in Response to Cognitive Stimulation in Healthy Ageing and Mild Cognitive Impairment

Table 6

Effect of WML-by-timepoint interaction on extracted functional networks.

Cluster level FWE	Cluster extent (voxels)	score at local maximum	Hemisphere	Brodmann area	Talairach coordinates			Brain region
					Healthy controls: positive interaction between vascular burden group and timepoint on functional connectivity of the posterior DMN
0.006	462	4.65	R	7	28	-57	54	Precuneus
		4.29	R	7	34	-56	54	Superior parietal lobule
		3.92	R	7	18	-48	54	Precuneus
		3.54	R	40	32	-42	52	Inferior parietal lobule
		3.46	R	7	20	-63	57	Superior parietal lobule
		3.37	R	40	36	-44	54	Inferior parietal lobule
		3.18	R	40	36	-50	47	Inferior parietal lobule
0.031	351	4.4	L	7	-26	-56	47	Superior parietal lobule
		3.98	L	40	-40	-36	50	Inferior parietal lobule
		3.9	L	7	-18	-50	43	Precuneus
		3.66	L	40	-28	-36	53	Postcentral gyrus
		3.5	L	40	-36	-40	55	Inferior parietal lobule
		2.93	L	7	-22	-51	58	Superior parietal lobule
		2.64	L	7	-34	-54	52	Superior parietal lobule
MCI: positive interaction between vascular burden group and timepoint on functional connectivity of the salience network
0.036	358	3.54	R		34	-13	12	Claustrum
		3.36	R	13	38	-3	13	Insula
		3.33	R	13	38	9	16	Insula
		3.49	R		34	10	7	Claustrum
		2.98	R		34	4	9	Claustrum
		2.79	R	13	32	-22	20	Insula
All: interaction between vascular burden and timepoint on functional connectivity of the posterior DMN in participants with low CR
0.013	277	3.83	R	24	16	4	37	Cingulate gyrus
		3.77	R	24	4	2	37	Cingulate gyrus
		3.50	R	24	18	-13	43	Cingulate gyrus

Note: only clusters surviving corrected threshold reported. FWE: family-wise error; R: right; L: left.