Writers and Readers of DNA Methylation/Hydroxymethylation in Physiological Aging and Its Impact on Cognitive Function

Table 1

Reported changes in DNMTs, Mecp2, and TETs expression in aging.

	Species	Age (months)	Reported change	Brain region	Reference
Dnmt1	m	18	=	Hippocampus	[12]
	m	24	↓	Frontal cortex	[82]
	r	30	↓	Hippocampus	[55]
	h		↓	Hippocampus	[55]
Dnmt3a1	m	18	↓	Hippocampus	[12]
	r	30	↓	Hippocampus	[55]
	h		↓	Hippocampus	[55]
Dnmt3a2	m	18	↓	Hippocampus	[12]
Dnmt3b	m	18	=	Hippocampus	[12]
	r	30	=	Hippocampus	[55]
	h		=	Hippocampus	[55]
Mecp2	m	31	↑	Whole brain	[61]
	h		↑	Cerebral cortex	[59, 60]
Tet1	m	18	↓	Hippocampus	[57]
	m	24	=	Frontal cortex	[82]
	m	31	↓	Whole brain	[61]
Tet2	m	18	↓	Hippocampus	[57]
	m	18	↓	Hippocampus	[58]
	m	31	↑	Whole brain	[61]
Tet3	m	18	=	Hippocampus	[58]
	m	24	=	Frontal cortex	[82]
	m	31	↓	Whole brain	[61]

Species: h: human, m: mouse, r: rat. Age is presented in months. Human postmortem samples include varied ages.