Research Article

Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity

Figure 4

Performance in all the cylinder, placing, and stepping tests is significantly impaired at 2 and 4 weeks following intrastriatal injections of QA. In contrast, performance on each of these tests is preserved, in a dose-related manner, by EC-GNDF implants with the higher dose-treated animals performing comparably to presurgery levels (preimplantation and prelesion). ; ; .
(a)
(b)
(c)