Brain Hemodynamic Intermediate Phenotype Links Vitamin B₁₂ to Cognitive Profile of Healthy and Mild Cognitive Impaired Subjects

Table 1

Predictive power of biochemical markers on cognitive profiles.

	PC1		PC7		PC12		PC15
	tHcy	.011	.9322	-.068	.6180	-.138	.3098	-.076	.5790
Folate	-.080	.5563	.021	.8841	-.409	.0021	.154	.2616
B12	.222	.1034	.171	.2071	-.147	.2746	.007	.9567
B12folate	.189	.1629	-.117	.3926	-.480	.0002	.012	.9254
B12tHcy	.037	.7844	.066	.6272	-.139	.3076	-.081	.5522
tHcyfolate	.149	.2689	.007	.9604	-.253	.0618	.428	.0011
Age	-.154	.2596	.431	.0009	-.175	.2004	.038	.7802
Education	.101	.4625	.346	.0097	.233	.0840	.031	.8185
MMSE scores	.553	.0000	-.042	.7674	-.042	.7621	.325	.0164
fMRI task accuracy	.037	.7912	-.029	.8342	.126	.3566	-.060	.6629

Model: PC_j=α+β tHcy+β folate+β B₁₂+β B₁₂folate+β B₁₂tHcy+β tHcyfolate+β age+β education+β MMSE+β fMRI task accuracy; italicized values represent uncorrected; bold values represent Bonferroni corrected; tHcy=homocysteine; MMSE=Mini Mental State Examination; PC=principal component.