Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer’s Disease

Figure 1

(a) Scheme showing the placement of recording electrodes and a cannula for injection of K18 in the locus coeruleus. (b, c) Relative power spectra in frequency (1-20 Hz (b) and 20-100 Hz (c)) for the CA1R and CA1L electrodes for buffer- (black, ) and K18- (green, ) injected mice, at recording weeks 1, 10, and 20. Insets indicate total relative power with no significance between group differences (two-sample -test) at 1-20 Hz and 20-100 Hz in b1 and b2, respectively. (d, e) Relative power spectra in CA1R and CA1L in low (4-6 Hz (d)) and high (6-8 Hz (e)) theta oscillations at recording weeks 1, 10, and 20. Data are presented as mean (across animals) values (and 95% CI). Horizontal lines above bar plots with asterisks indicate the presence of significant difference between buffer- and K18-injected animals (two-sample -test; ).

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