Ganglionic Long-Term Potentiation in Prehypertensive and Hypertensive Stages of Spontaneously Hypertensive Rats Depends on GABA Modulation

Figure 5

GABA-A receptors modulated LTP in SCG from adult (12 wo) SHR and young (6 wo) WKy rats. (a) Time course of synaptic potentiation, () recorded in SCG from 12 wo SHR in the absence (white circles) and presence of 2 μM bicuculline (half-full circles). (b) Bar plots of LTP decay and LTP extent showing that LTP was unmasked by GABA-A blockade (LTP decay of and LTP extent of for GABA-A subtype receptor blockade by bicuculline () and LTP decay of and LTP extent of without bicuculline (); and , respectively). (c) Time course of synaptic potentiation, () recorded in SCG from 6 wo WKy rats in the absence (white triangles) and in the presence of 2 μM bicuculline (half-full circles). (d) Bar plots of LTP decay and LTP extent showing that GABA-A blockade recovered LTP expression of SCG of 6 wo WKy rats (LTP decay of and LTP extent of for GABA blockade by bicuculline () and LTP decay of and LTP extent of without bicuculline (); and , respectively). Dotted lines in (a) and (c) indicate the LTP baseline (0.2).

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