Research Article

HMG-CoA Reductase Inhibitors Attenuate Neuronal Damage by Suppressing Oxygen Glucose Deprivation-Induced Activated Microglial Cells

Figure 2

Microglial activation in cerebral ischemic rats. (a) An infarcted area appeared in the dorsolateral cortex at ischemic day 1 following occlusion of the distal striatal branch of the MCA with TTC staining. White areas indicate infarcted tissues, whereas red areas indicate normal tissues. The periphery of the ischemic area marked by the line was defined as the peri-infarct area. (b) HIF1-α and Iba-1 were determined in the ischemic cerebral cortex by Western blotting using respective antibodies. Quantified HIF1-α and Iba-1 are expressed as ratios to the sham group. Values shown are expressed as the , which were assessed by one-way ANOVA followed by LSD test (homogeneity of variance was determined); . vs. the sham group and vs. the MCAO group.
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