Hsp70/Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model

Figure 3

Ultrastructural changes of spiral ganglion neuron. Electron transmission micrographs for SGNs in the control group (a/a), sound conditioning group (b/b), noise exposure group (c/c), and sound conditioning and noise exposure group (d/d). Green arrows showed that sound conditioning could enhance the electron density in the mitochondrion of spiral ganglion neuron cells and narrow the interspace of the mitochondrion. Red arrows indicated that noise exposure could result in the destruction of the mitochondrion in SGNs, the lower electron density, larger interspace, and the formation of the vacuole in the mitochondrion. Scale bars represent 1 μm and 0.2 μm. The account of a mitochondrion in spiral ganglion neuron cell of SD rat presented in (e) was analyzed with one-way ANOVA (; ), followed by Newman-Keuls’ post hoc test (×10³ units/mm², pictures from 3 animals/group, ; Ctrl vs. NE: , SC vs. Ctrl: ).