Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice
Mice undergoing neonatal MS exhibited visceral hypersensitivity. (a) Experimental paradigm of the maternal separation. (b) There was an insignificant difference in body weight between control and MS mice within 5 weeks after weaning (two-way ANOVA test, , , per group). (c) Schema of assessment of abdominal withdrawal reflex (AWR) and visceral pain threshold. (d) The visceral pain threshold of mice experiencing neonatal MS presented a significant decline (-test, , , per group). (e) The AWR score displayed a significant increase in MS mice subjected to pressure stimuli at 40 mmHg (Bonferroni post hoc test, ), 60 mmHg (Bonferroni post hoc test, ), and 80 mmHg (Bonferroni post hoc test, ), respectively (two-way ANOVA test, , , per group). Data are expressed as ; and .