Based on Systematic Pharmacology: Molecular Mechanism of Siwei Jianbu Decoction in Preventing Oxaliplatin-Induced Peripheral Neuropathy

Figure 7

Compared with mice in the CONTROL group, p-p38, p-ERK1/2, and NF-κB in the OXA group were activated. Compared with the OXA group, the same proteins in the treatment groups were mostly decreased (a, c, and d). The O+J12(L) group showed better preventive effects than the O+J12(H) group in p-p38 (d). Otherwise, the high-dose group was better than the NF-κB (a) group. In conclusion, J12 prevents oxaliplatin-induced NF-κB (a), p-ERK1/2 (b), and p-p38 (d) activation in the DRG. vs. Control, ; vs. Control, ; ^# vs. OXA, ; ^## vs. OXA, , ^### vs. OXA, , .

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