An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice

Figure 4

Manhattan plot of linkage to hearing phenotypes. QTL mapping identified one novel QTL on Chr 16 and one known QTL on Chr 11 for all three hearing phenotypes at 8, 16, and 32 kHz (a–c). The -axis denotes a position on the mouse genome, in megabases (Mb), while the -axis gives the –log(p) of linkage. The red line indicates a significant threshold for a genome-wide scan at a LOD score of 4 (equal to –log(p) of 4). Maps were computed with GEMMA using LOCO option. All analyses were performed on GeneNetwork.