An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice
Table 1
List of the protein-coding genes within the QTL region of Chr 16.
Entrez ID
Symbol
Location (Chr and Mb)
Distance to QTL peak (Mb)
Variant
Expression
Candidates rank
224273
Crybg3
16 : 59.490775
-10.11
Nonsynonymous SNP
High
Top
56297
Arl6
16 : 59.613321
-9.99
Nonsynonymous SNP
High
Top
13837
Epha3
16 : 63.545218
-6.05
Nonsynonymous SNP
High
Top
110920
Hspa13
16 : 75.75519
6.16
Nonsynonymous SNP
High
Top
78749
Filip1l
16 : 57.353277
-12.25
Nonsynonymous SNP
Low
Median
71223
Gpr15
16 : 58.717435
-10.88
Nonsynonymous SNP
Low
Median
328699
Gabrr3
16 : 59.407382
-10.19
Nonsynonymous SNP
Low
Median
13840
Epha6
16 : 59.641433
-9.96
Nonsynonymous SNP
Low
Median
15557
Htr1f
16 : 64.924729
-4.68
Frameshift
Low
Median
74185
Gbe1
16 : 70.313949
0.71
Nonsynonymous SNP
Low
Median
67742
Samsn1
16 : 75.858794
6.26
Nonsynonymous SNP
Low
Median
28185
Tomm70a
16 : 57.121714
-12.48
NA
High
Median
52633
Nit2
16 : 57.156665
-12.44
NA
High
Median
67581
Tbc1d23
16 : 57.168858
-12.43
NA
High
Median
71027
Tmem30c
16 : 57.266139
-12.33
NA
High
Median
12837
Col8a1
16 : 57.624256
-11.98
NA
High
Median
73379
Dcbld2
16 : 58.408426
-11.19
NA
High
Median
12892
Cpox
16 : 58.670208
-10.93
NA
High
Median
68146
Arl13b
16 : 62.793308
-6.81
NA
High
Median
19128
Pros1
16 : 62.854307
-6.75
NA
High
Median
72020
Zfp654
16 : 64.780347
-4.82
NA
High
Median
106143
Cggbp1
16 : 64.852001
-4.75
NA
High
Median
68942
Chmp2b
16 : 65.539133
-4.06
NA
High
Median
73569
Vgll3
16 : 65.815015
-3.78
NA
High
Median
19876
Robo1
16 : 72.027551
2.43
NA
High
Median
268902
Robo2
16 : 73.891976
4.29
NA
High
Median
54613
St3gal6
16 : 58.469742
-11.13
NA
Low
Low
106338
Nsun3
16 : 62.732444
-6.87
NA
Low
Low
68159
Stx19
16 : 62.814676
-6.79
NA
Low
Low
239857
Cadm2
16 : 66.655416
-2.94
NA
Low
Low
224344
Rbm11
16 : 75.592844
5.99
NA
Low
Low
69457
Tmem45a2
16 : 57.036967
-12.56
NA
NA
Low
66497
Cmss1
16 : 57.302
-12.30
NA
NA
Low
224250
Cldnd1
16 : 58.72791
-10.87
NA
NA
Low
67014
Riox2
16 : 59.47177
-10.13
NA
NA
Low
224291
Csnka2ip
16 : 64.47781
-5.12
NA
NA
Low
18736
Pou1f1
16 : 65.520629
-4.08
NA
NA
Low
224318
Speer2
16 : 69.856874
0.26
NA
NA
Low
52645
D16Ertd519e
16 : 70.616425
1.02
NA
NA
Low
751561
Mir691
16 : 74.34199
4.74
NA
NA
Low
102467647
n-TIaat1
16 : 75.434179
5.83
NA
NA
Low
320355
Lipi
16 : 75.540514
5.94
NA
NA
Low
Note: This list excluded the 25 olfactory receptor genes. indicates that the genes are expressed in hair cells, epithelial nonhair cells, or the cochlear duct. Expression data were extracted from the gEAR portal (https://umgear.org/). Expression value greater than 1000 is defined as high expression. NA: data not available.
