The Effects of 1 mA tACS and tRNS on Children/Adolescents and Adults: Investigating Age and Sensitivity to Sham Stimulation
Analyses on response to sham groups: For nonresponders to sham, the linear mixed model for the SI 1 mV MEP amplitudes revealed a significant effect of stimulation and time. An asterisk indicates . (a) The individual response to sham for all 43 participants and mean SI 1 mV MEPs for the children/adolescents and adults group. (b) Mean SI 1 mV MEP amplitudes (± SEM) of stimulation conditions. The -axis depicts normalized and log-transformed MEP amplitudes. For nonresponders, post hoc tests showed significant higher SI 1 mV amplitudes following 140 Hz tACS compared to sham stimulation. Also, we found significant lower amplitudes following 20 Hz tACS compared to sham stimulation. (c) Time course of mean SI 1 mV MEP amplitudes (± SEM) for each response group and each stimulation. The -axis depicts the timepoints before and after stimulation. The -axis displays normalized MEP amplitudes. We found increase amplitudes 0, 30, and 60 minutes following 140 Hz tACS, as well as 30 and 60 minutes following tRNS. The inhibitory effect of 20 Hz tACS has only been demonstrated in comparison to sham, but not for the baseline poststimulation comparison.
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