Toll-Like Receptor 2 Attenuates Traumatic Brain Injury-Induced Neural Stem Cell Proliferation in Dentate Gyrus of Rats
Immunofluorescence (IF) microphotographs in the dentate gyrus (DG) of the DG in sham and TBI groups at different time points. (a) BrdU-labelled NSCs (red fluor), expression of TLR2 (green fluor), cell nuclei (blue fluor), and BrdU+/TLR2+/DAPI+ cells indicated that TLR2 expression in labelled proliferating cells was possible NSCs; (b) BrdU+ cells showed the proliferation of NSCs in the DG during different time points posttrauma. BrdU+ cells were more in the TBI group than that in the sham group (), and numbers of these cells were significantly different among different time points posttrauma (#); (c) numbers of BrdU+/TLR2+ cells indicated that the expression of TLR2 was quite different in proliferating cells of the DG among different time points posttrauma. There were more BrdU+ cells in the TBI group than that in the sham group (), and the numbers of these cells are obviously different among different time points posttrauma (#). Scale bar: 50 μm; data is shown as .
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