Neural Plasticity / 2021 / Article / Fig 6

Research Article

Molecular Mechanism for PACAP 38-Induced Neurite Outgrowth in PC12 Cells

Figure 6

(a) Examination of pathways involved in protrusion extension (20 μm or more) by PACAP in inhibitor experiments. vs PACAP 10−7 M. Control: PACAP free; CHIR99021: GSK-3β inhibitor; LY294002: GSK-3β activator; H89: PKA inhibitor; U0126: MEK/ERK inhibitor; GF109203X: PKC inhibitor; purvalanol A: CDK5 inhibitor; Y27632: rock inhibitor. (b) Examination of pathways involved in protrusion extension (less than 20 μm) by PACAP in inhibitor experiments. vs PACAP 10−7 M. Control: PACAP free; CHIR99021: GSK-3β inhibitor; LY294002: GSK-3β activator; H89: PKA inhibitor; U0126: MEK/ERK inhibitor; GF109203X: PKC inhibitor; purvalanol A: CDK5 inhibitor and Y27632: rock inhibitor. (c) Examination of the pathways involved in protrusion extension in PC12 cells by PACAP using inhibitor experiments. →: pathways involved in process extension by PACAP; ⤏: pathways that are less involved in PACAP-induced protrusion extension.
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