Ketamine Induces Lasting Antidepressant Effects by Modulating the NMDAR/CaMKII-Mediated Synaptic Plasticity of the Hippocampal Dentate Gyrus in Depressive Stroke Model

Figure 2

Effects of ketamine on the behaviors of depressive-like MCAO rats. (a) Comparison of the immobility duration of the study groups after ketamine administration (OFT). (b) Representative movement tracks of different groups (OFT). (c) Rearing counts of various groups after ketamine treatment. (d) Changes in distance travelled after ketamine treatment. (e) Temporal improvements in average speed after ketamine administration. (f) Variations in explorative time spent in the central zone of each group. (g) Variations in time spent in the corner zone after ketamine treatment. (h) Changes in sucrose consumption after ketamine administration (SPT). (i) Differences in water consumption between groups at various time points. (j) Temporal variations in sucrose intake preference after ketamine treatment. 1w: 1 week. One-way ANOVA followed by Tukey’s multiple comparison tests. per group. , , , and .

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