The Wnt/β-Catenin Pathway Regulated Cytokines for Pathological Neuropathic Pain in Chronic Compression of Dorsal Root Ganglion Model
Intraperitoneal injection of XAV939 attenuated mechanical allodynia and decreased TNF-α and IL-18 levels in serum after CCD. (a) Schematic time course for acclimation, CCD surgery, intraperitoneal injection of XAV939, behavioral testing, and sacrifice. (b) MWT measured on 0, 1, 3, 5, and 7 days after CCD treatment (). Two-way ANOVA. Western blot showing active β-catenin expression in (c) DRG and (d) SCDH (). ELISA showing the expression of (e) TNF-α and (f) IL-18 in the serum of rats after intraperitoneal injection of XAV939 (). Serum was collected at different time points after CCD. One-way ANOVA. Bars represent group .####, CCD+vehicle versus sham; , CCD+XAV939 versus CCD+vehicle.
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