Dose-Dependent Pattern of Cochlear Synaptic Degeneration in C57BL/6J Mice Induced by Repeated Noise Exposure

<div>High-intensity (103 and 106 dB SPL) repeated noise-induced permanent effects on (a) DPOAE, (b–d) ABR wave I amplitudes, (e) ribbon synapse counts, and (f) MOC efferent synaptic quantification. Representative IF images of morphometric analysis for groups (g) 103 dB SPL and (h) 106 dB SPL at the frequency of 22.6 kHz; white arrows indicate significant morphometric changes (the scale bar indicates 10 <i>μ</i>m). Two-way ANOVA with Bonferroni post hoc tests were used to compare the difference between groups. The error bar represents the SEM for 8-12 mice in each group. 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Neural Plasticity

fig6

Figure 6

Figure 6: Dose-Dependent Pattern of Cochlear Synaptic Degeneration in C57BL/6J Mice Induced by Repeated Noise Exposure 