Identification of Novel Compound Heterozygous MYO15A Mutations in Two Chinese Families with Autosomal Recessive Nonsyndromic Hearing Loss

Figure 4

(a) Codon and amino acid coding diagram of the variant c.2802_2812del (p.Gln937Leufs39) of the proband II-1 of Family 1. The red letters indicate the changed amino acids and the site of the stop codon. In the mutant, no. 975 amino acid was converted into a termination codon. (b) Evolutionary conservation of no. 1894 and no. 2114 amino acid (red). Mutated site is indicated by an asterisk.

(a)

(b)