[Retracted] Molecular Basis of GABA Hypofunction in Adolescent Schizophrenia-Like Animals

Figure 1

Mice administrated with MK-801 on PND 10 showed schizophrenia-like behaviors in adolescence. (a) C57BL/6 male mice intraperitoneally received two consecutive injections of MK-801 (0.5 mg/kg) or saline on PND 10 with an interval of 8 h. Behavioral tests were performed from PND 35. (b) Time spends in the open () and closed arms, . (c) There was no significant difference in the baseline startle response amplitude between MK-801-treated and control groups, . (d) Prepulse inhibition was significantly inhibited at 85 dB in MK-801-injected mice (). (e) Nesting building score was significantly lower in MK-801-treated mice, . (f) The nesting building image between MK-801-treated and control mice. (g) MK-801-treated mice showed longer latency in entering the escape chamber (, , two-way ANOVA). Data were represented as . of saline and . , , . Student’s -test for two groups’ comparison. Two-way ANOVA by post hoc Tukey’s multiple comparison for two factors and two group analysis.

(a)

(b)

(c)

(d)

(e)

(f)

(g)