Research Article

Effect of Propionic Acid on Diabetes-Induced Impairment of Unfolded Protein Response Signaling and Astrocyte/Microglia Crosstalk in Rat Ventromedial Nucleus of the Hypothalamus

Table 3

Structural ER parameters after metformin and propionate administration on the background of T2DM.

GroupsControl groupT2DM groupT2DM+metformin groupT2DM+PA groupT2DM+metformin and PA group

Relative area of ER membranes (Smembr),#
Relative area of ER cisterns (Scist),#,#
Ratio Scist/Smembr,#
Total fraction of ER in the cell
Ratio of the area of the perinuclear space/length of the nucleus perimeter,#

Note: Values are given as (); vs. control, vs. T2DM, # vs. metformin administration, and @ vs. PA administration.