Neural Plasticity

Plasticity in Neurogenetic Disorders


Publishing date
29 Jun 2012
Status
Published
Submission deadline
03 Feb 2012

Lead Editor

1Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, Canada M5S 1A8

2Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, HSC 1R1, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1

3Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5

4Waisman Center for Developmental Disabilities, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, WI 53705, USA


Plasticity in Neurogenetic Disorders

Description

Over the next few decades, the study of neurogenetic disorders will continue to expand our knowledge of the development and function of the nervous system. The greatest challenges in the field of neurogenetic disorders will not be in the identification of disease-associated genes, but will rather be in defining the molecular mechanisms by which the genetic mutations confer disease risk and phenotype. Neural plasticity is a dynamic nervous system process that orchestrates structural and functional alterations in response to experience. The study of neural plasticity provides a basic and powerful approach for unraveling the complexities of the nervous system. Investigation of plastic changes in neurogenetic disorders will shed light on the molecular and cellular mechanisms that govern the formation and function of the nervous system. It may also lead to the discovery of potential therapeutic targets for pathological conditions, such as mental retardation, neurodegeneration, epilepsy, autism, and other neurological disorders.

This special issue will focus on the most recent developments and ideas in the study of neural plasticity in neurogenetic disorders, with a tentative emphasis on neurodevelopmental disorders, such as fragile X syndrome and Rett syndrome. We invite investigators to contribute original articles, as well as review articles, that will showcase current efforts in the field of neurogenetic disorders. Potential topics include, but are not limited to:

  • Structural and functional neural plasticity in patients and animal models of neurogenetic disorders
  • Molecular and cellular mechanisms underlying plastic changes in neurogenetic disorders
  • Neural and behavioral responses to potential therapeutic strategies involving neural plasticity for neurogenetic disorders
  • Genetic manipulation of neural plasticity in animal models and its translational relevance to human neurogenetic disorders
  • Basic and preclinical studies aimed at understanding the genetic mechanisms underlying plastic alterations in nervous system disorders

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/np/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 812472
  • - Editorial

Recent Progress in Understanding Plasticity in Neurogenetic Disorders

Hansen Wang | Cara J. Westmark | ... | Laurie C. Doering
  • Special Issue
  • - Volume 2012
  • - Article ID 976164
  • - Research Article

Hippocampal CA1 Pyramidal Neurons of Mecp2 Mutant Mice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage

Christopher A. Chapleau | Elena Maria Boggio | ... | Lucas Pozzo-Miller
  • Special Issue
  • - Volume 2012
  • - Article ID 589524
  • - Review Article

Animal Models of Psychiatric Disorders That Reflect Human Copy Number Variation

Jun Nomura | Toru Takumi
  • Special Issue
  • - Volume 2012
  • - Article ID 346053
  • - Review Article

Induced Pluripotent Stem Cells to Model and Treat Neurogenetic Disorders

Hansen Wang | Laurie C. Doering
  • Special Issue
  • - Volume 2012
  • - Article ID 682712
  • - Review Article

Lessons Learned from the Transgenic Huntington's Disease Rats

Rinske Vlamings | Dagmar H. Zeef | ... | Yasin Temel
  • Special Issue
  • - Volume 2012
  • - Article ID 467251
  • - Research Article

Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome

Markus Heinen | Moritz M. Hettich | ... | Dan Ehninger
  • Special Issue
  • - Volume 2012
  • - Article ID 279834
  • - Review Article

Synaptic Plasticity and Learning in Animal Models of Tuberous Sclerosis Complex

Timo Kirschstein
  • Special Issue
  • - Volume 2012
  • - Article ID 171639
  • - Review Article

Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics

Nicole Créau
  • Special Issue
  • - Volume 2012
  • - Article ID 101542
  • - Review Article

From Abnormal Hippocampal Synaptic Plasticity in Down Syndrome Mouse Models to Cognitive Disability in Down Syndrome

Nathan Cramer | Zygmunt Galdzicki
  • Special Issue
  • - Volume 2012
  • - Article ID 197491
  • - Review Article

Astrocytes and Developmental Plasticity in Fragile X

Connie Cheng | Mary Sourial | Laurie C. Doering
Neural Plasticity
 Journal metrics
Acceptance rate45%
Submission to final decision82 days
Acceptance to publication40 days
CiteScore3.330
Impact Factor3.591
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