Interactions between the two cerebral hemispheres are required for all major functions of the brain. Communication between the hemispheres is ensured by the corpus callosum, the largest fiber tract in the telencephalon, and by other smaller commissures. The objective of this special issue is to provide an overview of how callosal connections develop, function, and change in response to activity and experience. Special attention will also be given to studies of callosal agenesis and to alterations of interhemispheric connectivity caused by age and CNS disorders.

We welcome manuscripts related to the development, function, and plasticity of interhemispheric connections, in physiological and pathological conditions. The issue is open to reviews and original articles in humans and in animal models. Potential topics include, but are not limited to:

• Early stages of assembly of callosal connectivity and molecular mechanisms governing such processes
• Physiological and anatomical studies of callosal connections
• Experience- and activity-dependent maturation of interhemispheric projections
• Changes in structure and function of the callosum with age and in pathological conditions
• Studies of callosal agenesis in humans and animals
• Comparative studies of callosal connections across mammals

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/np/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: