Neural Plasticity

DNA Damage, Neurodegeneration, and Synaptic Plasticity


Status
Published

Lead Editor

1Istituto Superiore di Sanità, Rome, Italy

2Universidad Miguel Hernández, Alicante, Spain

3Institute of Applied Physiology Ulm, Heidelberg, Germany

4Technische Universität München, Munich, Germany


DNA Damage, Neurodegeneration, and Synaptic Plasticity

Description

Unrepaired DNA lesions and deficiencies in DNA repair systems are implicated in the progressive neuronal loss observed in many neurodegenerative pathologies including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). Whether the increased level of DNA damage in neurodegenerative disorders is a consequence rather than the cause of previous neurodegenerative events remains to be established.

Neuronal DNA damage and repair may also play a role in cognitive function and dysfunction.

The formation of double strand breaks (DSBs), the most lethal form of DNA damage, may be a physiological process that modifies chromatin organization and gene expression involved in information processing, learning, and memory and may be caused by normal brain activity. Conversely, pathologically elevated β-amyloid peptide (Aβ), a major culprit for the pathogenesis of AD, worsens DNA damage by eliciting aberrant synaptic activity.

Interestingly, the involvement of ataxia-telangiectasia mutated protein (ATM, a PI 3-kinase DSB repair protein) in synaptic plasticity provides a new attractive explanation for the severe neurological symptoms observed in ataxia-telangiectasia patients and also suggests a possible function of ATM not associated with DNA repair.

We invite authors to submit original research articles as well as review articles that will contribute to and stimulate our knowledge of the mechanisms underlying DNA damage in neurodegenerative disorders, the understanding of the molecular and cellular basis of neurodegenerative diseases, and the mechanisms involved in cognitive impairment associated with neurodegeneration.

Potential topics include, but are not limited to:

  • Role of DNA damage in neurodegenerative diseases
  • DNA damage in the “normal” aging brain
  • Neurological consequences of unrepaired DNA damage
  • Consequences of the failure of DNA repair
  • Natural and transgenic animal models for studying neurodegenerative disorders
  • Defects in synaptic plasticity associated with neurodegeneration
  • DNA damage/repair and its links to cognitive functions
  • Innovative therapeutic strategies for treatment of neurodegenerative diseases

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 1206840
  • - Editorial

DNA Damage, Neurodegeneration, and Synaptic Plasticity

Daniela Merlo | Inmaculada Cuchillo-Ibañez | ... | Gerhard Rammes
  • Special Issue
  • - Volume 2016
  • - Article ID 6391686
  • - Review Article

Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration

Sheela Vyas | Ana João Rodrigues | ... | Ioannis Sotiropoulos
  • Special Issue
  • - Volume 2016
  • - Article ID 8987928
  • - Research Article

Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition

Jianying Zeng | Jenny Libien | ... | A. Iván Hernández
  • Special Issue
  • - Volume 2016
  • - Article ID 3619274
  • - Review Article

The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease

Laura Narciso | Eleonora Parlanti | ... | Eugenia Dogliotti
  • Special Issue
  • - Volume 2016
  • - Article ID 3830424
  • - Research Article

Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease

G. D’Arcangelo | D. Grossi | ... | C. Frank
  • Special Issue
  • - Volume 2016
  • - Article ID 3707406
  • - Research Article

The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex

Emmanuelle Gruz-Gibelli | Natacha Chessel | ... | Armand Savioz
  • Special Issue
  • - Volume 2016
  • - Article ID 8501693
  • - Review Article

Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment

Jaume Folch | Dmitry Petrov | ... | Antoni Camins
  • Special Issue
  • - Volume 2016
  • - Article ID 6097107
  • - Review Article

Neuroprotective Transcription Factors in Animal Models of Parkinson Disease

François-Xavier Blaudin de Thé | Hocine Rekaik | ... | Rajiv L. Joshi
  • Special Issue
  • - Volume 2016
  • - Article ID 1752176
  • - Research Article

Identification and Characterization of the V(D)J Recombination Activating Gene 1 in Long-Term Memory of Context Fear Conditioning

Edgardo Castro-Pérez | Emilio Soto-Soto | ... | Sandra Peña de Ortiz
Neural Plasticity
 Journal metrics
Acceptance rate43%
Submission to final decision71 days
Acceptance to publication44 days
CiteScore3.330
Impact Factor3.591
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