Neural Plasticity

Reestablishing Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells for Hearing Loss 2021


Publishing date
01 Sep 2021
Status
Closed
Submission deadline
23 Apr 2021

Lead Editor

1Southeast University, Nanjing, China

2University of Massachusetts Amherst, Amherst, USA

3Dalhousie University, Halifax, Canada

4University of Tampere, Tampere, Finland

5Tulane University, New Orleans, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Reestablishing Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells for Hearing Loss 2021

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Hearing loss is considered the most common sensory disorder in the human population that occurs at all ages world-wide, and sensorineural hearing loss (SNHL) is the most common type of hearing loss. Various insults could induce SNHL, including acoustic trauma, ear and brain tumors, aging, noise exposure, or ototoxic medications or chemicals. SNHL is caused by the irreversible loss of sensory hair cells and the degeneration of spiral ganglion neurons. SNHL is not yet curable because of the irreversible death of hair cells and the degeneration of spiral ganglion neurons in the cochlea.

In recent years, exciting animal studies on signaling pathway manipulation, gene therapy, and stem cell transplantation, as well as pharmaceutical agents, demonstrated that hair cells and spiral ganglion neurons could be regenerated; and indicated that hearing loss might eventually be curable in the future. Neural plasticity is the key feature for spiral ganglion neurons and hair cells and is especially important for the new regenerated spiral ganglion neurons and hair cells.

The aim of this Special Issue is to solicit original research articles, as well as review articles, focusing on the recent advances in re-establishing the neural plasticity of regenerated spiral ganglion neurons and sensory hair cells. Researchers and clinicians are encouraged to submit their work including both basic and translational research.

Potential topics include but are not limited to the following:

  • Gene therapy for inherited hearing loss
  • Gene therapy for hair cell regeneration
  • Inner ear mini organ formation
  • Hidden hearing loss
  • The application of biomaterials in regeneration
  • Signaling mechanisms
  • Cytoskeletal regulation
  • Hair cell regeneration
  • Spiral ganglion neuron regeneration
  • Spiral ganglion neuron refinement and retraction
  • Spiral ganglion neuron neurites pruning
  • Application of biomaterials in improving the plasticity of spiral ganglion neurons
  • Ribbon synapse plasticity
  • Noise and drug-induced changes in hair cell and spiral ganglion neuron plasticity
  • Genetic aspects regulating plasticity

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 5567174
  • - Research Article

ROS-Induced Oxidative Damage and Mitochondrial Dysfunction Mediated by Inhibition of SIRT3 in Cultured Cochlear Cells

Lingjun Zhang | Zhengde Du | ... | Shusheng Gong
  • Special Issue
  • - Volume 2021
  • - Article ID 6151973
  • - Research Article

Hearing Screening Combined with Target Gene Panel Testing Increased Etiological Diagnostic Yield in Deaf Children

Le Xie | Yue Qiu | ... | Yu Sun
  • Special Issue
  • - Volume 2021
  • - Article ID 4784385
  • - Review Article

Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions

Huanyu Mao | Yan Chen
  • Special Issue
  • - Volume 2021
  • - Article ID 5511010
  • - Review Article

Autophagy: A Novel Horizon for Hair Cell Protection

Chang Liu | Zhiwei Zheng | ... | Yingzi He
  • Special Issue
  • - Volume 2021
  • - Article ID 8706400
  • - Research Article

Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt/β-Catenin and Sonic Hedgehog Pathways

Jin Huang | Liang Zhou | ... | Tinghua Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 9919977
  • - Research Article

Dose-Dependent Pattern of Cochlear Synaptic Degeneration in C57BL/6J Mice Induced by Repeated Noise Exposure

Minfei Qian | Qixuan Wang | ... | Zhiwu Huang
  • Special Issue
  • - Volume 2021
  • - Article ID 9979157
  • - Research Article

Deletion of Clusterin Protects Cochlear Hair Cells against Hair Cell Aging and Ototoxicity

Xiaochang Zhao | Heidi J. Henderson | ... | Yi Li
  • Special Issue
  • - Volume 2021
  • - Article ID 9950533
  • - Research Article

Canonical Wnt Signaling Pathway on Polarity Formation of Utricle Hair Cells

Di Deng | Xiaoqing Qian | ... | Dongdong Ren
  • Special Issue
  • - Volume 2021
  • - Article ID 9957712
  • - Research Article

Identification of Novel Compound Heterozygous MYO15A Mutations in Two Chinese Families with Autosomal Recessive Nonsyndromic Hearing Loss

Xiao-Hui Wang | Le Xie | ... | Wei-Jia Kong
  • Special Issue
  • - Volume 2021
  • - Article ID 5528434
  • - Research Article

Next-Generation Sequencing Identifies Pathogenic Variants in HGF, POU3F4, TECTA, and MYO7A in Consanguineous Pakistani Deaf Families

Xueshuang Mei | Yaqi Zhou | ... | Hongyi Hu
Neural Plasticity
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.