Neural Plasticity

The Role of Dentate Gyrus Neurogenesis in Neuropsychiatric Disorders

Publishing date
19 Jul 2013
Submission deadline
01 Mar 2013

1Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA

2Department of Psychology, University of Illinois, Chicago, IL, USA

The Role of Dentate Gyrus Neurogenesis in Neuropsychiatric Disorders


The hippocampus is tactically situated in the brain such that it has reciprocal connections to several other regions involved in emotional behaviors, such as stress responses and positive and negative reinforcement. Alterations in these emotional behaviors can be considered as precursors for development of neuropsychiatric disorders such as anxiety, depression, and addiction. Adult neurogenesis in the dentate gyrus (DG) of the hippocampus is a new undisputed form of spontaneous plasticity, and most of the emotional behaviors implicated in neuropsychiatric disorders are known to inhibit DG neurogenesis.

Therefore, the normalization of impaired DG neurogenesis during recovery or abstinence may be required to initiate normal neuroplasticity in the hippocampus which could be critical for recovery.

We particularly take an interest in manuscripts that report on correlations between neuropsychiatric-related traits and adult hippocampal neurogenesis. Reviews or original papers that focus on demonstrating a role for hippocampal neurogenesis in recovery or etiology of neuropsychiatric disorders in human or animal models are welcome. Moreover, papers demonstrating reversal of impaired neurogenesis and emotional behaviors by therapeutic interventions such as antidepressants, physical activity, or enriched environment would be of great interest. In the context of the above topics, importance will be also given to manuscripts and reviews that report advances in methodological details for analysis of DG neurogenesis. Potential topics include, but are not limited to:

  • Novel methods of detecting DG neurogenesis in preclinical and clinical models:
    • Immunohistochemical methods to detect developmental stages of neurogenesis
    • Transgenic models for visualization of neurogenesis
    • Novel tools developed to measure levels of neurogenesis in vivo and ex vivo
    • Methods for knocking-down neurogenesis
  • Molecular and epigenetic mechanisms regulating DG neurogenesis
  • Adult neurogenesis and the plasticity of the DG network
    • Functional studies on integration of adult-born neurons
    • Computational theories
  • Novel stimuli (with specific focus on neuropsychiatric disorders) that regulate DG neurogenesis
    • Addictive disorders
    • Affective disorders
    • Therapeutic interventions
  • A critical evaluation of the role of DG neurogenesis in neuropsychiatric disorders
    • Limitations
    • Future approaches

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2013
  • - Article ID 584382
  • - Editorial

The Role of Dentate Gyrus Neurogenesis in Neuropsychiatric Disorders

M. Julia García-Fuster | Justin S. Rhodes | Chitra D. Mandyam
  • Special Issue
  • - Volume 2013
  • - Article ID 537265
  • - Review Article

Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication

Fuencisla Pilar-Cuéllar | Rebeca Vidal | ... | Elsa M. Valdizán
  • Special Issue
  • - Volume 2013
  • - Article ID 318596
  • - Review Article

Immature Dentate Gyrus: An Endophenotype of Neuropsychiatric Disorders

Hideo Hagihara | Keizo Takao | ... | Tsuyoshi Miyakawa
  • Special Issue
  • - Volume 2013
  • - Article ID 698528
  • - Review Article

Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy

Shaefali P. Rodgers | Melissa Trevino | ... | J. Leigh Leasure
  • Special Issue
  • - Volume 2013
  • - Article ID 805497
  • - Review Article

The Neural Plasticity Theory of Depression: Assessing the Roles of Adult Neurogenesis and PSA-NCAM within the Hippocampus

Steven R. Wainwright | Liisa A. M. Galea
  • Special Issue
  • - Volume 2012
  • - Article ID 854285
  • - Review Article

Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders

Heechul Jun | Syed Mohammed Qasim Hussaini | ... | Mi-Hyeon Jang
  • Special Issue
  • - Volume 2012
  • - Article ID 283829
  • - Research Article

Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior

Megan P. Hicks | Kelly C. Wischerath | ... | M. Foster Olive
  • Special Issue
  • - Volume 2012
  • - Article ID 832757
  • - Review Article

Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update

Gerburg Keilhoff | Paolo Fusar-Poli | Axel Becker
Neural Plasticity
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