Neural Plasticity

Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders


Status
Published

1Mclean Hospital, Belmont, USA

2Otto-von-Guericke University, Magdeburg, Germany

3Concordia University, Montreal, Canada

4University of Alabama at Birmingham, Birmingham, USA


Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders

Description

Recent studies have revealed that clock genes are rhythmically expressed throughout the brain and play critical roles in the regulation of normal brain processes. For example, clock genes are involved in regulating rhythms in long-term potentiation, dendritic spines, receptor trafficking, and neuronal activity in brain region and cell type specific manners. Current evidence suggests that circadian rhythms regulate short and long-term synaptic plasticity in neural circuits that underlie rhythmic behaviors, including respiration, blood pressure, cortisol, and locomotor activity, among others. Despite the evidence that circadian rhythms are involved in the regulation of several neural processes and in turn behaviors, this topic has not been extensively studied thus far, and there is much that is not known as to how and why circadian rhythms regulate such processes. Although mammalian circadian rhythms are controlled predominantly by the suprachiasmatic nucleus, recent advances made in this field on the emerging roles of clock gene rhythms across brain regions have suggested that the circadian system is involved in brain region specific regulation of cell activity and specific behaviors. Furthermore, recent studies have suggested a critical role of the circadian system in several disorders, including major depression, bipolar disorder, schizophrenia, anxiety, stress regulation, age related cognitive deficits including Alzheimer’s disease, eating disorders, drug addiction, and alcoholism. The impact of circadian rhythm disruption on cognitive function, mood, and cardiovascular health, in populations of shift workers and frequent travelers, may also be due to underlying effects of circadian disruption on synaptic plasticity. This research area is thus at the interface of neuroscience, cell biology, endocrinology, and psychiatry.

This special issue aims to create a multidisciplinary collection of recent advances in the role of the circadian system in normal brain functions and psychiatric disorders. We invite authors to contribute original research articles as well as review articles that will illustrate and stimulate the continuing effort to understand the role of the circadian system in the regulation of normal brain processes and in diseases states, as well as potential use of the circadian system in development of therapeutic strategies.

Potential topics include but are not limited to the following:

  • Recent advances in our understanding of peripheral brain oscillators
  • Clock gene regulation of neuronal function including synaptic plasticity
  • Clock gene regulation of glial cells (oligodendrocytes and astrocytes) and microglia
  • Circadian rhythm abnormalities in mood disorders and psychotic disorders
  • Circadian disruption and health in shift workers and frequent travelers
  • Role of circadian rhythms in cognition and aging
  • Circadian rhythms in regulation of reward processes and addiction
  • Interactions between the circadian system and stress response system

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5892657
  • - Editorial

Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders

Harry Pantazopoulos | Karen Gamble | ... | Shimon Amir
  • Special Issue
  • - Volume 2018
  • - Article ID 6238989
  • - Review Article

Clocking In Time to Gate Memory Processes: The Circadian Clock Is Part of the Ins and Outs of Memory

Oliver Rawashdeh | Rex Parsons | Erik Maronde
  • Special Issue
  • - Volume 2018
  • - Article ID 5147585
  • - Review Article

Photoperiod-Induced Neuroplasticity in the Circadian System

Alessandra Porcu | Malini Riddle | ... | David K. Welsh
  • Special Issue
  • - Volume 2018
  • - Article ID 7292540
  • - Review Article

Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms

Kaitlin H. Snider | Kyle A. Sullivan | Karl Obrietan
  • Special Issue
  • - Volume 2018
  • - Article ID 5689165
  • - Review Article

Perinatal Programming of Circadian Clock-Stress Crosstalk

Mariana Astiz | Henrik Oster
  • Special Issue
  • - Volume 2018
  • - Article ID 5868570
  • - Review Article

Precision Light for the Treatment of Psychiatric Disorders

Sevag Kaladchibachi | Fabian Fernandez
  • Special Issue
  • - Volume 2018
  • - Article ID 8217345
  • - Review Article

Photoperiodic Programming of the SCN and Its Role in Photoperiodic Output

Michael C. Tackenberg | Douglas G. McMahon
  • Special Issue
  • - Volume 2017
  • - Article ID 8140737
  • - Review Article

The Role of Mammalian Glial Cells in Circadian Rhythm Regulation

Donají Chi-Castañeda | Arturo Ortega
  • Special Issue
  • - Volume 2017
  • - Article ID 4723836
  • - Review Article

Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse

Aliza K. De Nobrega | Lisa C. Lyons
  • Special Issue
  • - Volume 2017
  • - Article ID 5720842
  • - Review Article

Neural Mechanisms of Circadian Regulation of Natural and Drug Reward

Lauren M. DePoy | Colleen A. McClung | Ryan W. Logan
Neural Plasticity
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Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore6.900
Impact Factor3.093
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