Neural Plasticity

Glutamate Receptors in Alzheimer’s Disease: Mechanisms and Therapies


Publishing date
24 Jun 2016
Status
Published
Submission deadline
05 Feb 2016

Lead Editor

1University of Queensland, Brisbane, Australia

2Massachusetts Institute of Technology, Cambridge, USA


Glutamate Receptors in Alzheimer’s Disease: Mechanisms and Therapies

Description

Alzheimer’s disease (AD) manifests as a progressive loss in memory and cognition, commonly associated with elevated levels of amyloid-beta peptide (Aβ) and hyperphosphorylated tau in the brain. There is currently no cure for AD as its causes remain poorly understood. Accumulating evidence suggests that synaptic dysfunction is a major contributor early in disease pathogenesis prior to neuronal loss. Glutamatergic neurotransmission is particularly vulnerable to the neurotoxic effect of Aβ and hyperphosphorylated tau. Indeed, these toxic species act in synergy and severely disrupt excitatory synaptic transmission, synaptic plasticity, and network activity, mainly due to the loss of AMPA receptors, as well as NMDA receptors.

Evidence also suggests that Aβ-induced synaptic loss and cell death are mediated by overstimulation of NMDA receptors, which could be ameliorated by NMDAR antagonist, such as memantine, an FDA-approved medication for AD. More recently, the identification of mGluR5 as a coreceptor for Aβ and a potential role for metabotropic-like function of NMDA receptors have provided novel insights into the molecular basis of AD. Therefore, understanding the underlying molecular mechanisms and complex signalling pathways by which these toxic species exert strong detrimental effects on synaptic function may yield novel strategies for the development of meaningful therapeutic agents. We invite authors to submit original research and review articles that explore aspects of glutamate receptor function in AD models, both in vitro and in vivo.

Potential topics include, but are not limited to:

  • Effects of Aβ oligomers and tau hyperphosphorylation on glutamate receptor function and their underlying mechanisms of action
  • Mechanisms of long-term plasticity in Alzheimer’s disease
  • Mechanisms of homeostatic synaptic plasticity in Alzheimer’s disease
  • Mechanisms of network dysfunction in Alzheimer’s disease
  • Mechanisms of excitotoxicity in Alzheimer’s disease
  • Modeling Alzheimer’s disease in vitro and in vivo (IPSC, CRISPR/Cas9, and transgenic technologies)
  • Glutamate receptors as potential therapeutic targets for Alzheimer’s disease

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8256196
  • - Editorial

Glutamate Receptors in Alzheimer’s Disease: Mechanisms and Therapies

Victor Anggono | Li-Huei Tsai | Jürgen Götz
  • Special Issue
  • - Volume 2016
  • - Article ID 6427537
  • - Review Article

Synaptic Cell Adhesion Molecules in Alzheimer’s Disease

Iryna Leshchyns’ka | Vladimir Sytnyk
  • Special Issue
  • - Volume 2016
  • - Article ID 8136925
  • - Review Article

Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function

Marija Kamceva | Jessie Benedict | ... | Paul J. Lombroso
  • Special Issue
  • - Volume 2016
  • - Article ID 2371970
  • - Review Article

Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease

Holly Stefen | Chanchanok Chaichim | ... | Thomas Fath
  • Special Issue
  • - Volume 2016
  • - Article ID 2123748
  • - Research Article

Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity

Sung-Soo Jang | Sara E. Royston | ... | Hee Jung Chung
  • Special Issue
  • - Volume 2016
  • - Article ID 3204519
  • - Review Article

Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking

Sumasri Guntupalli | Jocelyn Widagdo | Victor Anggono
  • Special Issue
  • - Volume 2016
  • - Article ID 7969272
  • - Review Article

Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity

Sung-Soo Jang | Hee Jung Chung
  • Special Issue
  • - Volume 2016
  • - Article ID 4626593
  • - Review Article

The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer’s Disease

Yu-Long Lan | Shuang Zou | ... | Shao Li
Neural Plasticity
 Journal metrics
Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore5.200
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Impact Factor3.599
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