Neural Plasticity

Cannabinoids in the Brain: New Vistas on an Old Dilemma


Status
Published

1University of Copenhagen, Copenhagen, Denmark

2Université de Montréal, Montréal, Canada


Cannabinoids in the Brain: New Vistas on an Old Dilemma

Description

The use of cannabis as a therapeutic and recreational substance goes back to thousands of years throughout Asia, Middle East, Southern Africa, and South America. The discovery of Δ9-THC by Mechoulam and Gaoni in the mid-sixties as the major psychoactive constituent of Cannabis sativa led to another important discovery, namely, its specific binding site that was isolated and cloned in 1990 (Matsuda et al., 1990). This binding site was coined CB1R and triggered a number of investigations on its expression, localization, and function within the body tissue, including the brain in various species. This was followed by the discovery in 1992 of the first endocannabinoid, anandamide (Devane et al., 1992), followed by another cannabinoid receptor CB2R and a second endocannabinoid called 2-arachidonoylglycerol (2-AG). Later, the enzymes responsible for their synthesis and degradation (FAAH and NAPE) were identified.

However, the recreational use and side effects of cannabinoids have been subjected to numerous studies throughout history, but the investigation of the endocannabinoid system and its potential therapeutic use is rather new, and a lot of attention has been devoted not only to its specific expression in the brain but also to its functions. These studies have recently received substantial attention from pharmaceutical companies as a potential source of novel treatment. Additionally, the dilemma of legalizing the use of cannabis in some countries makes the investigation on cannabinoid systems more momentous. This special issue is therefore timely and will bring historical and groundbreaking novel research on the role of these cannabinoid receptors in the mammalian brain with an emphasis on the ensuing clinical implications.

In line with the known effects of Cannabis sativa, papers dealing with the various effects of cannabinoid receptors on sensory, motor, and cognitive functions will be welcome.

Potential topics include, but are not limited to:

  • Evolution and the endocannabinoid system
  • The retinal endocannabinoid system: an overview
  • Expression of CB2 in the central nervous system
  • Pharmacology of CB1 and CB2 receptors
  • The endocannabinoid system and axon guidance
  • Plasticity of the endocannabinoid system in the mouse
  • Role of the cannabinoid receptors in the primate retinal function
  • Expression of cannabinoid receptors in the retinogeniculostriate pathway
  • Cannabis and binocular depth perception
  • Age related changes of anandamide metabolism
  • Cannabis and memory
  • GPR55: an atypical cannabinoid receptor
  • Cannabinoids as therapeutics agents
  • Cannabis in the treatment of glaucoma
  • Cannabinoid in brain cancers
  • Mental illness and cannabis
  • Interaction between cannabis and ethanol in fetal development
  • Alternative interacting sites and novel cannabinoid receptors
  • Cannabinoids on Parkinson disease and related neurodegenerative disorders
  • Treatment of childhood seizures with cannabinoids
  • Legal issues with medicinal use of CBs

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 9146713
  • - Editorial

Cannabinoids in the Brain: New Vistas on an Old Dilemma

Maurice Ptito | Christian Casanova | Jean-François Bouchard
  • Special Issue
  • - Volume 2016
  • - Article ID 1253245
  • - Research Article

Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

Joseph Bouskila | Vanessa Harrar | ... | Maurice Ptito
  • Special Issue
  • - Volume 2016
  • - Article ID 6526437
  • - Research Article

Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users

Samantha J. Broyd | Lisa-marie Greenwood | ... | Nadia Solowij
  • Special Issue
  • - Volume 2016
  • - Article ID 3127658
  • - Research Article

A Comparative Analysis of the Endocannabinoid System in the Retina of Mice, Tree Shrews, and Monkeys

Joseph Bouskila | Pasha Javadi | ... | Maurice Ptito
  • Special Issue
  • - Volume 2016
  • - Article ID 9364091
  • - Review Article

The Endocannabinoid System as a Therapeutic Target in Glaucoma

Elizabeth A. Cairns | William H. Baldridge | Melanie E. M. Kelly
  • Special Issue
  • - Volume 2016
  • - Article ID 2916732
  • - Review Article

The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications

Thomas Schwitzer | Raymund Schwan | ... | Vincent Laprevote
  • Special Issue
  • - Volume 2016
  • - Article ID 8373020
  • - Review Article

Endogenous and Synthetic Cannabinoids as Therapeutics in Retinal Disease

Despina Kokona | Panagiota-Christina Georgiou | ... | Kyriaki Thermos
  • Special Issue
  • - Volume 2016
  • - Article ID 6481862
  • - Research Article

Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait

M. Rodríguez-Arias | C. Roger-Sánchez | ... | M. A. Aguilar
  • Special Issue
  • - Volume 2016
  • - Article ID 2426398
  • - Review Article

Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification

Jantana Keereetaweep | Kent D. Chapman
  • Special Issue
  • - Volume 2016
  • - Article ID 9247057
  • - Review Article

Expression and Function of the Endocannabinoid System in the Retina and the Visual Brain

Jean-François Bouchard | Christian Casanova | ... | William John Redmond
Neural Plasticity
 Journal metrics
Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore6.900
Impact Factor3.093
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