Neural Plasticity

Reestablishing Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells for Hearing Loss 2020


Publishing date
01 Sep 2020
Status
Closed
Submission deadline
24 Apr 2020

Lead Editor

1Southeast University, Nanjing, China

2University of Massachusetts Amherst, Amherst, USA

3Dalhousie University, Halifax, Canada

4University of Tampere, Tampere, Finland

5Tulane University, Louisiana, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Reestablishing Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells for Hearing Loss 2020

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Hearing loss is considered the most common sensory disorder in the human population that occurs at all ages worldwide, and sensorineural hearing loss (SNHL) is the most common type of hearing loss. Various insults could induce SNHL, including acoustic trauma, ear and brain tumors, aging, noise exposure, or ototoxic medications or chemicals. SNHL is caused by the irreversible loss of sensory hair cells and the degeneration of the spiral ganglion neurons. SNHL is not yet curable because of the irreversible death of hair cells and the degeneration of spiral ganglion neurons in the cochlea. Recent years, exciting animal studies on signaling pathway manipulation, gene therapy, and stem cell transplantation as well as pharmaceutical agents demonstrated that hair cells and spiral ganglion neurons could be regenerated and indicated that hearing loss might eventually be curable in the future. Neural plasticity is a key feature for spiral ganglion neurons and hair cells and is especially important for the new regenerated spiral ganglion neurons and hair cells. This special issue will focus on recent advances in reestablishing the neural plasticity of regenerated spiral ganglion neurons and sensory hair cells.

In this Special Issue, we invite authors to submit high-quality original research articles and reviews. Researchers and clinicians are encouraged to submit their work including both basic and translational research.

Potential topics include but are not limited to the following:

  • Signaling mechanisms
  • Cytoskeletal regulation
  • Hair cell regeneration
  • Spiral ganglion neuron regeneration
  • Spiral ganglion neuron refinement and retraction
  • Spiral ganglion neuron neurites pruning
  • Application of biomaterials in improving the plasticity of spiral ganglion neuron
  • Ribbon synapse plasticity
  • Noise and drug induced changes in hair cell and spiral ganglion neuron plasticity
  • Genetic aspects regulating plasticity
  • Gene therapy of hearing loss
  • The application of Biomaterials in regeneration
  • Inner ear progenitors and mini organ formation

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 4909237
  • - Review Article

Hair Cell Protection from Ototoxic Drugs

Peng Wu | Xianmin Wu | ... | He Li
  • Special Issue
  • - Volume 2021
  • - Article ID 8855055
  • - Research Article

Low-Intensity Ultrasound Causes Direct Excitation of Auditory Cortical Neurons

Xiaofei Qi | Kexin Lyu | ... | Jie Tang
  • Special Issue
  • - Volume 2020
  • - Article ID 8885813
  • - Research Article

Developmental and Functional Hair Cell-Like Cells Induced by Atoh1 Overexpression in the Adult Mammalian Cochlea In Vitro

Lingyi Kong | Yuan Xin | ... | Juanmei Yang
  • Special Issue
  • - Volume 2020
  • - Article ID 9387560
  • - Research Article

Distinct Expression Patterns of Apoptosis and Autophagy-Associated Proteins and Genes during Postnatal Development of Spiral Ganglion Neurons in Rat

Shule Hou | Penghui Chen | ... | Jun Yang
  • Special Issue
  • - Volume 2020
  • - Article ID 8850447
  • - Review Article

Research Progress of Hair Cell Protection Mechanism

Yurong Mu | Hongguo Su | ... | Dan Li
  • Special Issue
  • - Volume 2020
  • - Article ID 8823785
  • - Research Article

Hsp70/Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model

Guoxia Zhu | Yongxiang Wu | ... | Jianhua Qiu
  • Special Issue
  • - Volume 2020
  • - Article ID 9460364
  • - Research Article

Altered Brain Activity and Functional Connectivity in Unilateral Sudden Sensorineural Hearing Loss

Jiawei Chen | Bo Hu | ... | Lianjun Lu
  • Special Issue
  • - Volume 2020
  • - Article ID 8851525
  • - Research Article

Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis

Na Zhang | Jing Cai | ... | Wenwen Liu
  • Special Issue
  • - Volume 2020
  • - Article ID 4106949
  • - Research Article

Effects of SoundBite Bone Conduction Hearing Aids on Speech Recognition and Quality of Life in Patients with Single-Sided Deafness

Qiong Luo | Ying Shen | ... | Zhengnong Chen
  • Special Issue
  • - Volume 2020
  • - Article ID 3108490
  • - Research Article

The Influence of Cochlear Implant-Based Electric Stimulation on the Electrophysiological Characteristics of Cultured Spiral Ganglion Neurons

Na Shen | Lei Zhou | ... | Shufeng Li
Neural Plasticity
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Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore5.200
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.