Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease

Table 1

Adult neurogenesis in HD patients and rodent models.

S.no	HD model	Neurogenic region	Neurogenesis	Reference(s)
1	Human	Subependymal layer	Increased	Curtis et al. 2003 [37]
2	QA-lesioned rat	Subventricular zone	Increased	Tattersfield et al. 2004 [38]
3	R6/1 mouse	Hippocampus	Decreased	Lazic et al. 2004 [39]
				Gil et al. 2005 [40]
4	R6/2 mouse	Hippocampus	Decreased	Phillips et al. 2005 [41]
				Kohl et at. 2007 [42]
5	R6/2 mouse	Subventricular zone	No Change	Phillips et al. 2005 [41]
				Kohl et al. 2010 [43]
6	TgHD rat	Hippocampus	Decreased	Kandasamy et al. 2010 [121]
7	R6/2 mouse	Olfactory Bulb	Decreased	Kohl et al. 2010 [43]
8	YAC 128 mouse	Hippocampus	Decreased	Simpson et al. 2010 [122]