Administration of Recombinant Heat Shock Protein 70 Delays Peripheral Muscle Denervation in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Muscles with type 1 fibers have increased expression of Hsp70 as compared to muscles with predominantly Type 2 fibers. (a) Images of representative Western blots probed for Hsp70 or actin (loading control). (b) Quantification of Hsp70 expression was performed with densitometry analysis confirmed increased expression of Hsp70 in muscles containing type 1 fibers. There was no significant difference in Hsp70 expression between WT and SOD1 muscles and treatment with rhHsp70 did not affect this expression. Statistical significance was determined using a two-way ANOVA followed by Tukey-Kramer post hoc test ( *).
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