T2-weighted images (TR 3,440 msec/TE 89.4 msec) at 42 years old. (a) A cross-section at the pontine level exhibits bilateral and symmetrical signal loss with central hyperintense abnormalities in the dentate nucleus with cerebeller cortical atrophy. (b) An image of a midbrain section demonstrates the symmetrical increased signal intensity involving the substantia nigra. A decreased signal change is observed in the red nucleus. (c) An image at the level of the basal ganglia shows hyperintensity with a band of surrounding hypointensity affecting the putamen and pallidum. Foggy high signal changes can be seen in the inner part of the thalamus bilaterally. (d) An image of a section of the central part of the lateral ventricles. (e) An image of a section of the cerebral cortex. The signal change is not evident.
