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Neurology Research International
Volume 2012, Article ID 278725, 7 pages
Review Article

From Transcriptome to Noncoding RNAs: Implications in ALS Mechanism

1Laboratory of Experimental Neurobiology, IRCCS National Neurological Institute “C. Mondino,” 27100 Pavia, Italy
2Department of Neurological Sciences, University of Pavia, 27100 Pavia, Italy

Received 24 February 2012; Revised 27 April 2012; Accepted 11 May 2012

Academic Editor: Vincenzo Di Lazzaro

Copyright © 2012 Stella Gagliardi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the last years, numerous studies have focused on understanding the metabolism of RNA and its implication in disease processes but abnormal RNA metabolism is still unknown. RNA plays a central role in translating genetic information into proteins and in many other catalytic and regulatory tasks. Recent advances in the study of RNA metabolism revealed complex pathways for the generation and maintenance of functional RNA in amyotrophic lateral sclerosis (ALS). Interestingly, perturbations in RNA processing have been described in ALS at various levels such as gene transcription, mRNA stabilization, transport, and translational regulations. In this paper, we will discuss the alteration of RNA profile in ALS disease, starting from transcription, the first step leading to gene expression, through the posttranscriptional regulation, including RNA/DNA binding proteins and aberrant exon splicing to protein noncoding RNAs, as lncRNA and microRNA.