DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease

<table>Study design schematic. DTI data were preprocessed by FDT (FSL) to obtain MD and FA maps. Structural T1 data were corrected in intensity by FreeSurfer and segmented in brain, grey and white matter volumes by FAST (FSL). Hippocampi and PC/PCC were segmented automatically by FIRST and AAL template registration and then registered on DTI maps. Tracts connecting hippocampus to PC/PCC (hipp-PC/PCC) were identified by probabilistic tractography within FDT and then registered back on structural T1 data. Normalized volumes, MD, and FA values were obtained for GM, WM, hippocampi, PC/PCC, and hipp-PC/PCC tracts.</table>

Neurology Research International

fig1

Figure 1

Figure 1: DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease 