DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease
Table 2
Relative volumes in CTRL, MCI, and AD patients.
CTRL ()
MCI ()
AD ()
Student t-test*
Mean
(SD)
Mean
(SD)
Mean
(SD)
CTRL versus MCI
CTRL versus AD
MCI versus AD
Brain tissue
0.7635
(0.0188)
0.7550
(0.0250)
0.6733
(0.1791)
n.s.
0.041
n.s.
White matter
0.3951
(0.0194)
0.3841
(0.0274)
0.3385
(0.0881)
n.s.
n.s.
n.s.
Grey matter
0.3684
(0.0151)
0.3709
(0.0131)
0.3349
(0.0927)
n.s.
0.013
n.s.
Left PC/PCC
0.0141
(0.0009)
0.0145
(0.0016)
0.0132
(0.0012)
n.s.
0.033
0.046
Right PC/PCC
0.0128
(0.0009)
0.0126
(0.0015)
0.0120
(0.0011)
n.s.
n.s.
n.s.
Left hippocampus
0.0028
(0.0003)
0.0025
(0.0004)
0.0022
(0.0004)
0.045
<0.001
n.s.
Right hippocampus
0.0029
(0.0003)
0.0026
(0.0004)
0.0023
(0.0003)
0.029
<0.001
n.s.
Left hipp-PC/PCC
0.0234
(0.0087)
0.0178
(0.0075)
0.0119
(0.0027)
n.s.
<0.001
0.031
Right hipp-PC/PCC
0.0265
(0.0099)
0.0190
(0.0071)
0.0143
(0.0038)
0.047
0.001
n.s.
* Statistical analysis: Student t-test for independent sample; is considered significant. Values are expressed in mean (SD). CTRL: healthy controls; MCI: mild cognitive impairment; AD: Alzheimer’s disease; n.s.: not significant; Hipp-PC/PCC: hippocampus to PC/PCC tract.
