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Neurology Research International
Volume 2012, Article ID 561494, 15 pages
Review Article

The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury

Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195-6320, USA

Received 15 October 2011; Revised 25 November 2011; Accepted 13 December 2011

Academic Editor: Tara DeSilva

Copyright © 2012 Ryan M. McAdams and Sandra E. Juul. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Perinatal brain injury frequently complicates preterm birth and leads to significant long-term morbidity. Cytokines and inflammatory cells are mediators in the common pathways associated with perinatal brain injury induced by a variety of insults, such as hypoxic-ischemic injury, reperfusion injury, toxin-mediated injury, and infection. This paper examines our current knowledge regarding cytokine-related perinatal brain injury and specifically discusses strategies for attenuating cytokine-mediated brain damage.