Magnetic Resonance Imaging in Amyotrophic Lateral Sclerosis
Figure 2
Cortical brain regions with impaired structural connectivity in ALS patients. (a) The network-based statistic procedure revealed a subnetwork of brain regions showing significantly reduced structural connectivity in ALS patients, compared to healthy controls. (b) Using an NBS threshold of ( being the number of nodes of the network) a similar but more extended network was revealed. The model-free approach revealed a sub-network consistent with known motor regions, including precentral and paracentral gyri (primary motor), and caudal middle frontal and superior frontal gyri (supplemental motor areas, BA 6). Adapted from Verstraete and coworkers [46].
