Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease
(a) Age effect on the longitudinal followup of GMV for the three APOE groups, illustrating the significant interaction between age and the APOE ɛ4. ɛ4 (–/–): noncarriers for the APOE ɛ4 allele, and ɛ4 (+/–): heterozygous for the APOE ɛ4 allele, ɛ4 (+/+): homozygous for the APOE ɛ4 allele (adapted with permission from ). (b) Regression of the normalized volume of the prefrontal callosal subregion on age in APOE ε4 carriers (red) and noncarriers (blue). Thick lines show linear regression lines and dotted lines 95% mean confidence intervals of the slope. Formulas denote regression lines. Normalization was done to total intracranial volume (adapted with permission from ).
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