Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease

Figure 6

AGE by GENE interactions in the “novel versus familiar” contrast of the encoding task. (a) Regions showing significant interaction between AGE and GENE factors (𝑃<0.05, corrected for multiple comparisons) with plots of percentage signal change in brain regions showing group-related differences where ε4 (orange) defines ε4-carriers and NC (green) defines noncarriers. (b) ROIs for the left and right hippocampi overlaid on a structural image (left) with associated plot of average hippocampal percentage signal change showing significant age-by-gene interaction (left hippocampus: 𝑃=0.002, right hippocampus: 𝑃=0.003) (adapted with permission from [33]).

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