Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease
AGE by GENE interactions in the “novel versus familiar” contrast of the encoding task. (a) Regions showing significant interaction between AGE and GENE factors (, corrected for multiple comparisons) with plots of percentage signal change in brain regions showing group-related differences where ε4 (orange) defines ε4-carriers and NC (green) defines noncarriers. (b) ROIs for the left and right hippocampi overlaid on a structural image (left) with associated plot of average hippocampal percentage signal change showing significant age-by-gene interaction (left hippocampus: , right hippocampus: ) (adapted with permission from ).
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