Review Article
Genetics of Cerebral Vasospasm
Table 2
Summary of preclinical in vivo gene therapy experiments.
| Gene | Reference | Method | Organism | Expression | Effect |
| β-galactosidase | [53] | Adenovirus | Canine | Leptomeninges, ependyma, and BA adventitia | — | CGRP | [54] | Adenovirus | Rabbit | CSF, BA adventitia, and perivascular tissue | Attenuation of vasoconstriction | HMOX | [55] | Adenovirus | Rat | HO-1 mRNA and protein in BA adventitia | Attenuation of vasoconstriction | eNOS | [49] | Adenovirus | Canine | BA adventitia | Attenuation of vasoconstriction | Superoxide dismutase | [56] | Adenovirus | Rabbit | BA adventitia | Attenuation of vasoconstriction | CGRP | [57] | Protein | Rat | — | Attenuation of vasoconstriction | HMOX | [58] | Arginine | Rat | All layers of BA | Attenuation of vasoconstriction |
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