Table 1: Clinical features and their prevalence according to mutation.

Clinical featuresMFN2OPA1OPA3PINK1

Axonal neuropathy++++
Optic atrophy+++++++
Deafness+++
Limb girdle weakness++
Progressive external ophthalmoplegia++++
Cataract+++
Resting tremor, rigidity, and bradykinesia+++
White matter periventricular involvement++
3-Methylglutaconic aciduria+++
Cognitive decline++++
Spasticity++++
Ataxia++

+++: typical; ++: common; +: infrequent.