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Neurology Research International
Volume 2013, Article ID 597034, 9 pages
Research Article

Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population

1Department of Medicine, University of Padova, 35128 Padova, Italy
2MRC Unit for Lifelong Health and Ageing at UCL, London WC2B 4AN, UK
3Department of Internal Medicine, Hospital of Rovigo, 45100 Rovigo, Italy
4General Direction, University Hospital of Verona, 37126 Verona, Italy
5Department of General Psychology, University of Padova, 35128 Pdova, Italy

Received 10 June 2013; Accepted 27 July 2013

Academic Editor: Mamede de Carvalho

Copyright © 2013 Edoardo Casiglia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To verify whether the C825T polymorphism of the GNB3 influences the response to neuropsychological tests, mini-mental state examination, digit span (DS), immediate and delayed prose memory, memory with interference at 10 and 30 seconds (MI 10 and 30), trail making tests (TMTs) A and B, abstraction task, verbal fluency (VF) test, figure drawing and copying, overlapping figures test and clock test were performed in 220 elderly men and women free from clinical dementia and from neurological and psychiatric diseases randomly taken from the Italian general population and analysed across the C825T polymorphism. The performance of DS, immediate and delayed prose memory, VF, and TMTs was worse in subjects who were TT for the polymorphism in comparison to the C-carriers. The performance of all tests declined with age. In the case of DS, immediate and delayed prose memory, MI 10 and VF, this trend was maintained in the C-carriers but not in TT. In the case of prose memory, of memory with interference, and of VF, schooling reduced the detrimental interaction between age and genotype. The C825T polymorphism of GNB3 gene therefore influences memory and verbal fluency, being additive to the effects of age and partially mitigated by schooling.