Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population
Table 3
Multiple regression of the neuropsychological tests with age, education, and C825T polymorphism of GNB3 gene.
Tests
Age (years)
Education (years)
C825T of GNB3 (TT versus C-carriers)
(SE)
(SE)
(SE)
MMSE
−0.21 (0.04)
<0.0001
0.07 (0.09)
0.4 (ns)
−0.15 (9.24)
0.5 (ns)
Digit span
−0.05 (0.01)
<0.001
0.04 (0.04)
0.3 (ns)
−0.30 (0.10)
<0.005
IPM
−0.17 (0.05)
<0.0001
0.44 (0.12)
<0.0001
−0.73 (0.32)
0.02
DPM
−0.36 (0.06)
<0.0001
0.58 (0.14)
<0.0001
−0.77 (0.32)
<0.05
MI 10
−0.14 (0.03)
<0.001
0.19 (0.08)
0.02
−0.18 (0.23)
0.4 (ns)
MI 30
−0.03 (0.04)
0.3 (ns)
0.35 (0.07)
<0.0001
0.10 (0.19)
0.3 (ns)
Verbal fluency
−0.19 (0.04)
<0.0001
0.23 (0.11)
<0.05
−0.80 (0.30)
<0.005
TMT A
1.32 (0.44)
<0.005
−2.47 (1.04)
<0.03
7.96 (3.12)
<0.01
TMT B
2.10 (1.02)
<0.05
−6.63 (2.47)
<0.01
18.80 (9.89)
0.06 (ns)
Figure drawing
−0.02 (0.01)
<0.01
0.01 (0.02)
0.9 (ns)
−0.07 (0.05)
0.1 (ns)
Figure copying
−0.03 (0.01)
<0.0001
0.04 (0.02)
0.4 (ns)
−0.07 (0.04)
0.1 (ns)
Abstraction
−0.09 (0.02)
<0.0001
0.22 (0.05)
<0.0001
0.01 (0.14)
0.9 (ns)
Overlapping figure
−0.58 (0.09)
<0.0001
1.00 (0.22)
<0.0001
−0.59 (0.61)
0.3 (ns)
Clock test
−0.15 (0.04)
<0.0001
0.16 (0.09)
0.1 (ns)
-0.46 (0.26)
0.1 (ns)
: coefficient of regression; SE: standard error of the coefficient. MMSE: mini-mental state examination; IPM and DPM: immediate and delayed prose memory; MI 10 and MI 30: memory with interference at 10 and 30 seconds; TMTs: trail making tests; ns: nonsignificant.
